The only O/U that will accept different barrels (other than dedicated skeet sets) that I can think of is the Valmet. It's a European gun that has a whole selection of barrels, including shotgun/rifle combos - kind of like the Thompson Center line. I used to see them advertised back in the 90's but haven't seen one in years.
The problem with interchangeable barrels is getting a perfect fit between the barrels and the receiver. With a 4-barrel skeet set, the barrels are all fit to the receiver at the factory. You could probably get different barrels for most any O/U but you'd have to send the gun in for fitting.
The problem with interchangeable barrels is getting a perfect fit between the barrels and the receiver. With a 4-barrel skeet set, the barrels are all fit to the receiver at the factory. You could probably get different barrels for most any O/U but you'd have to send the gun in for fitting.